ECEA 5934 Design
1st course in the Engineering Genetic Circuits Specialization
Instructor: Chris Myers,ÌýPhD, Professor
This course gives an introduction to the biology and biochemistry necessary to understand genetic circuits. It starts by providing an engineering viewpoint on genetic circuit design and a review of cells and their structure. The second module introduces genetic parts and the importance of standards followed by a discussion of genetic devices used within circuit design. The last two modules cover experimental techniques and construction methods and principles applied during the design process.
Learning Outcomes
- ÁñÁ«ÊÓƵ18 the field of synthetic biology through a brief examination of its history.
- Identify basic parts used in genetic circuits.
- Describe sequence ontologies and principles behind standards in engineering.
- Identify the underlying structure of devices and their connection to genetic parts.
- Design genetic circuits that execute combinational digital logic functions.
- Design genetic circuits that execute sequential digital logic functions.
- Distinguish between different experimental techniques used in genetic construction.
- Describe alternative assembly and DNA synthesis methods for genetic circuit construction.
- Outline areas of future work for the field.
- Describe alternative design styles that can help overcome design challenges.
- Identify ways genetic circuits may fail to perform correctly.
Syllabus
Duration: 4Ìýhours
This week gives a brief introduction to the biology and biochemistry necessary to understand genetic circuits. The material covered is only a basic overview, since it is usually the topic of whole courses. It should, however, give the grounding necessary to begin studying the modeling, analysis, and design of genetic circuits.
Duration: 7Ìýhours
This week highlights the importance of standards in synthetic biology as an engineering discipline. Furthermore, the week introduces genetic parts - the basic building used to construct genetic circuits.
Duration: 3 hours
This week introduces genetic devices, the aggregation of multiple genetic parts. Basic rules for composing, as well as different types of devices, are introduced, as well.
Duration: 4Ìýhours
This week introduces techniques used to construct a genetic circuit. This includes commonly used methods like polymerase chain reaction for cloning and DNA assembly methods. Finally, construction methods to assemble different genetic parts are presented.
Duration: 2Ìýhours
This week introduces practical challenges in realizing genetic circuit designs.Ìý
Duration: 2ÌýhoursÌý
To learn about ProctorU's exam proctoring, system test links, and privacy policy, visitÌýwww.colorado.edu/ecee/online-masters/current-students/proctoru.
Grading
Assignment | Percentage of Grade |
Instructions of accessing reading materials | 1% |
Brief Introduction to Biochemistry | 2% |
Resources | 2% |
SBOL Data Model | 2% |
Genetic Part Selection | 5% |
Basic Device Rules | 2% |
Genetic Logic Identification | 2% |
Genetic Device Design | 10% |
Experimental Techniques | 2% |
Genetic Construction Planning | 10% |
Potential Genetic Design Problems | 2% |
Genetic Circuit Design Final Project | 60% |
Letter Grade Rubric
Letter GradeÌý | Minimum Percentage |
A | 93% |
A- | 90% |
B+ | 86% |
B | 83% |
B- | 80% |
C+ | 76% |
C | 73% |
C- | 70% |
D+ | 66% |
D | 60% |
F | 0% |