Research
Studying the Infant Microbiome to Prevent Autoimmune Diseases
Autoimmune diseases such as allergies, asthma, and type 1 diabetes are prevalent at epidemic levels in industrialized countries, while significantly less common in non-industrialized regions. This disparity has been linked to the pivotal role of the early-life microbiome in immune development. Our lab is at the forefront of decoding how variations in the infant microbiome across different environments contribute to immune health. We focus on the impact of early microbial exposures, and assessing the effects of maternal transmission, environmental influences, and dietary factors on microbial colonization. Our research aims to prevent autoimmune diseases by developing early-life interventions, including probiotic formulations tailored to strengthen immune defenses from birth. This work not only enriches our comprehension of autoimmune disorders but also promises transformative strategies that could shield future generations from these conditions.
Understanding Microbiome Regulation via Mucosal Immunology
The intricate relationship between the human immune system and our microbiomes is central to our health. In our lab, we study this dynamic interplay using sophisticated immune profiling technologies. We investigate how immunoglobulin A (IgA) and other immune components engage with gut microbes, promoting health and preventing disease. Our research aims to reveal  insights into the regulatory mechanisms that govern immune responses and microbial balance within the gut. By mapping these interactions, we aim to unlock therapeutic approaches to promote robust health across adult populations and aid in the fight against disease like IBD.
Computational Method Development for Microbiome Research
A cornerstone of our research is the development of state-of-the-art computational tools to analyze and interpret complex microbiome data. Our lab develops and refines bioinformatics software that enables researchers worldwide to conduct detailed, strain-level comparisons and population genomic studies. These tools are crucial for advancing our understanding of microbial ecosystems and their impact on human health, allowing for more precise and predictive microbiological research.
Omics Analysis of Interesting Microbial Communities
 Beyond the human microbiome, our lab applies cutting-edge omics tools to explore the complex microbial communities found in environments ranging from wastewater and soil to streams and hospital rooms. These diverse ecosystems hold key insights into microbial dynamics, resistance patterns, and ecological impacts. By extending our advanced metagenomic  techniques to these varied settings, we aim to uncover the broader roles microbes play in environmental health and sustainability. This expansive research helps us understand microbial interactions in their natural contexts and informs strategies for managing microbial populations in both natural and built environments. Through this work, we contribute to the development of solutions for environmental conservation, public health, and biosecurity.
